Scientists Create New Antibody For Virus That Infects 95% of People
A crucial milestone. 
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Researchers at the Fred Hutchinson Cancer Center and University of Washington have developed a new antibody capable of blocking Epstein-Barr virus (EBV), an infection present in approximately 95 percent of the global adult population. While most infected individuals experience no noticeable symptoms, EBV establishes a permanent presence in the body once acquired and has been associated with various cancers, multiple sclerosis, and other serious medical conditions.
The scientific team identified antibodies that target two surface proteins on EBV particles, gp350 and gp42, which facilitate the virus’s ability to penetrate B cells—crucial components of the immune system. By blocking these proteins, the antibodies could theoretically prevent initial infection and potentially stop the virus from reactivating later in life. Testing in mice with human-like immune systems demonstrated that one candidate antibody successfully protected animals from EBV infection, representing a significant breakthrough in combating this widespread pathogen.
The research employed an innovative approach using genetically modified mice that produce human antibodies, increasing the likelihood of acceptance by the human body in future therapeutic applications. Scientists isolated ten promising antibodies from laboratory testing, with one showing particularly strong protective capabilities. This discovery holds particular promise for immunocompromised patients, especially organ and bone marrow transplant recipients who require immunosuppressive medications that leave them vulnerable to severe EBV-related complications.
While considerable additional research remains before human clinical trials can commence, scientists describe this development as a critical advancement in the ongoing effort to combat one of humanity’s most prevalent viruses.
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Originally reported by Sciencealert →
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